Holby City: Series 20
Main Cast:
- Guy Henry as Henrik Hanssen – Consultant General Surgeon/ CEO
- Hugh Quarshie as Ric Griffin – Consultant General Surgeon
- Rosie Marcel as Jac Naylor – Consultant Cardiothoracic Surgeon/ Darwin Clinical Lead
- Paul McGann as John Gaskell - Consultant Neurosurgeon/ Professor
- Bob Barrett as Sacha Levy – Consultant General Surgery
- Hermione Gulliford as Roxanna MacMillan - Consultant Neurosurgeon
- David Ames as Dominic Copeland – CT1 General Surgery/ Registrar General Surgeon
- Belinda Owusu as Nicky McKendrick - F1 Doctor
- Salma Hoque as Meena Chowdhury - F1 Doctor
- Alex Walkinshaw as Adrian 'Fletch' Fletcher – Director of Nursing
- Kaye Wragg as Estelle Di Lucca – Staff Nurse
- Lee Mead as Ben "Lofty" Chiltern - Staff Nurse
- Jaye Jacobs as Donna Jackson - Staff Nurse/ Senior Staff Nurse
Cast Changes:
Returning:
- Catherine Russell as Serena Campbell – Consultant General Surgeon/ Acting CEO (from episode 6)
- Jemma Redgrave as Bernie Wolfe - Consultant General Surgeon (TBC)
Departing:
- James Anderson as Oliver Valentine – Cardiothoracic Registrar (until episode 13)
Joining:
- Marcus Griffiths as Xavier 'Zav' Duval - Registrar General Surgeon (from episode 8)
Guest Cast:
- Jules Robertson as Jason Haynes - Porter
- Camilla Arfwedson as Zosia March (1 episode)
- Olivia Poulet as Abigail Tait - CEO (from episode 14)
Casualty Crossovers:
- Unknown
